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  #1  
Old Thu Jul 28, 2016, 09:30 PM
bailie bailie is offline
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Shingles vaccinations

Have any of you had your shingles vaccinations after transplant? How long after is it recommended? I have a friend who got shingles at about 1 year following transplant.
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age 70, dx RAEB-2 on 11-26-2013 w/11% blasts. 8 cycles Vidaza 3w/Revlimid. SCT 8/15/2014, relapsed@Day+210 (AML). Now(SCT-Day+1005). Prepping w/ 10 days Dacogen for DLI on 6/9/2017.
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  #2  
Old Thu Jul 28, 2016, 10:44 PM
bailie bailie is offline
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Found the answer From Fred Hutchinson Cancer Center in Seattle:

The Varicella-zoster (chickenpox/shingles) vaccine is currently not generally recommended, pending further research. If the benefits outweigh the risks, it may be given to help prevent chickenpox if the patient doesn't already have antibodies to the chickenpox virus.
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age 70, dx RAEB-2 on 11-26-2013 w/11% blasts. 8 cycles Vidaza 3w/Revlimid. SCT 8/15/2014, relapsed@Day+210 (AML). Now(SCT-Day+1005). Prepping w/ 10 days Dacogen for DLI on 6/9/2017.
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  #3  
Old Thu Jul 28, 2016, 10:51 PM
bailie bailie is offline
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Additionally,

Live attenuated varicella-zoster vaccine in hematopoietic stem cell transplantation recipients.
Issa NC1, Marty FM2, Leblebjian H3, Galar A4, Shea MM5, Antin JH6, Soiffer RJ6, Baden LR2.
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Abstract
Hematopoietic stem cell transplantation (HSCT) recipients are at risk for varicella-zoster virus (VZV) reactivation. Vaccination may help restore VZV immunity; however, the available live attenuated VZV vaccine (Zostavax) is contraindicated in immunocompromised hosts. We report our experience with using a single dose of VZV vaccine in 110 adult autologous and allogeneic HSCT recipients who were about 2 years after transplantation, free of graft-versus-host disease, and not receiving immunosuppression. One hundred eight vaccine recipients (98.2%) had no clinically apparent adverse events with a median follow-up period of 9.5 months (interquartile range, 6 to 16; range, 2 to 28). Two vaccine recipients (1.8%) developed a skin rash (one zoster-like rash with associated pain, one varicella-like) within 42 days post-vaccination that resolved with antiviral therapy. We could not confirm if these rashes were due to vaccine (Oka) or wild-type VZV. No other possible cases of VZV reactivation have occurred with about 1178 months of follow-up. Live attenuated zoster vaccine appears generally safe in this population when vaccinated as noted; the overall vaccination risk needs to be weighed against the risk of wild-type VZV disease in this high-risk population.
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age 70, dx RAEB-2 on 11-26-2013 w/11% blasts. 8 cycles Vidaza 3w/Revlimid. SCT 8/15/2014, relapsed@Day+210 (AML). Now(SCT-Day+1005). Prepping w/ 10 days Dacogen for DLI on 6/9/2017.
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  #4  
Old Fri Jul 29, 2016, 05:15 AM
lisa3112 lisa3112 is offline
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Thanks for info. I'm day 130 and haven't had any as yet. :-)
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Now 30yr old. Diagnosed AML dec 2015 (Most likely MDS prior). Trisomy 6. Runx1 mutation also. Had induction and consolidation chemo. Marrow failure ++ so SCT on 21st of March with MUD. Married with a 1yr old!
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  #5  
Old Fri Jul 29, 2016, 05:15 PM
GoodDay5150 GoodDay5150 is offline
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Hi Bailie. I think that I was vaccinated a few yrs after my transplant, (but I got shingles anyway) last Fall. They were super painful, and no matter whether I was sitting or standing or laying down, my clothes would rub against them; they were on my right thigh. I have known some people who have gotten them when they were the same age as I was, and these people did not have weakened immune systems like we have. I had a hard time sleeping for a few days, but they healed pretty quickly once I started taking an anti-viral.

Mario
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MARIO, 46, DIAG IN 2011 W/ PNH, MUD IN DEC 2011. MINI TRANS PSL DENVER/ SOME MILD GVHD.
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  #6  
Old Fri Jul 29, 2016, 08:56 PM
vickij vickij is offline
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Bailie

I am getting my vaccines now but was told when I started them to not get any live vaccines yet. I will see my Dr next month and nurse at Health Dept. wants me to ask him when I can get live vaccines since I have had all the other ones on the list.
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62 yr old female. dx AA 3/12.treated with ATG 4/12.dx MDS 4/13. MUD BMT on June 25th,2013
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  #7  
Old Sat Jul 30, 2016, 05:47 AM
lisa3112 lisa3112 is offline
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Also just
FYI my grandmother had really painful shingles and acupuncture helped her immensely. Cheers, Lisa.
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Now 30yr old. Diagnosed AML dec 2015 (Most likely MDS prior). Trisomy 6. Runx1 mutation also. Had induction and consolidation chemo. Marrow failure ++ so SCT on 21st of March with MUD. Married with a 1yr old!
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  #8  
Old Sat Jul 30, 2016, 08:57 AM
bailie bailie is offline
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I agree, shingles can be very serious. I was curious about what different doctors around the country feel about some of these things. What I have come to realize is that so many doctors have so many different ideas about some of these things concerning MDS, AML etc. There are so many unanswered questions because of the wide varieties in these diseases and patients. Educated guesses are all over the board.
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age 70, dx RAEB-2 on 11-26-2013 w/11% blasts. 8 cycles Vidaza 3w/Revlimid. SCT 8/15/2014, relapsed@Day+210 (AML). Now(SCT-Day+1005). Prepping w/ 10 days Dacogen for DLI on 6/9/2017.
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  #9  
Old Sat Jul 30, 2016, 08:15 PM
Cheryl C Cheryl C is offline
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I had shingles in my left buttock down into the left groin, earlier this year. It was extremely painful for several weeks, until I started to take olive leaf extract (1.5 times normal dose) as recommended by my brother. It resolved quickly after that.

After I recovered I investigated whether I should have the vaccine but I came up with contraindications for anyone with a compromised immune system.
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Dx MDS RAEB 10% blasts + hypogammaglobulinemia, Sep 2011. Jan 2012 BMB - blasts down to 2% w/out treatment so BMT cancelled. Re-diagnosis RCMD. On watch and wait since Feb 2012. IVIg 5-weekly. BMB Feb 2014 - no blast transformation. 2018 still stable.
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