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#1
Sat Jan 25, 2014, 12:26 PM
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Preventing relapse after SCT in high risk MDS??
I understand some centers are using SC Vidaza to prevent relapse after SCT in high risk patients and there is currently a study with oral Vidaza.
Does anyone know of publications on these options or if there are any other drugs being studied post transplant? Wife of Diver Down 
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#2
Sat Jan 25, 2014, 03:31 PM
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I will send studies when I get home, but the three strategies my doctor spoke of last week wetter 1) donor lymphocyte infusion 2) vidaza and 3) reduction in immune suppressants. They have been using vidaza for about 2 years with high risk patients, in some cases before any relapse.
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MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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#3
Sat Jan 25, 2014, 05:04 PM
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I had post-BMT Vidaza for 10 months, 5-day cycles subcutaneous injections, intended to help prevent relapse. So far, so good (knock wood). My transplant was at Johns Hopkins 11/30/2010. I was supposed to do 12 months but they thought it might be exacerbating GvHD so stopped at 10. I had no immunosuppressants (had post transplant cytoxan instead).
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com Last edited by mausmish : Sat Jan 25, 2014 at 05:49 PM.
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#4
Sat Jan 25, 2014, 11:59 PM
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Here are a couple of articles about the use of Vidaza and/or DLI for higher risk patients:
http://www.ncbi.nlm.nih.gov/pubmed/20672358 http://www.mdsbeacon.com/news/2011/0...er-transplant/
__________________
MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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