Home         Forums  

Go Back   Marrowforums > Treatments > Transplants
Register FAQ Search Today's Posts Mark Forums Read

Transplants Bone marrow and stem cell transplantation

Reply
 
Thread Tools Search this Thread
  #1  
Old Mon May 20, 2013, 01:13 AM
AAMarge AAMarge is offline
Member
 
Join Date: May 2013
Location: Minnesota
Posts: 4
Mixed chimerism after BMT for AA anyone?

My daughter had a BMT for AA in August of 2010-sibling donor. Things went well & she's been doing great with normal counts. Until January 2013. Platelets down as far as 26 & we are basically in transplant rescue mode-after 2.5 years! We have known that she ended up with mixed chimerism (donor cells plus her original cells both present). It had been stable since transplant, but now shows an increase in her cells. As her cells go up, counts go down.

Currently trying Prograf (couldn't tolerate cyclosporine), which has stopped the freefall, but has not increased her counts.

I know AA pts can have mixed chimerism because of the "gentler" conditioning. Anyone out there with any experience with mixed chimerism causing late problems? Results?
__________________
Connie, Mother of AA daughter (age 21) MSD BMT 8/2010; struggling with dropping blood counts in 2013 after 2 great years. Second BMT 11/4/13.
Reply With Quote
  #2  
Old Mon May 20, 2013, 07:47 PM
Cam Cam is offline
Member
 
Join Date: Oct 2012
Location: Jacksonville, Florida
Posts: 88
I don't have any experience with that form of Chimerism. But I am currently on Prograf for GVHD. I was on cyclosporine before. Prograf will suppress your Hemoglobin so be prepared for that. It will also give you loose stool. So be prepared for that.... I am about to be weaned off it. I can not wait for that issue to disappear.
__________________
Cam, BMT 12/6/12 for MDS, diagnosed August 2012 beat it in December 2012
Reply With Quote
  #3  
Old Tue Jul 29, 2014, 03:05 PM
AAMarge AAMarge is offline
Member
 
Join Date: May 2013
Location: Minnesota
Posts: 4
For anyone happening upon this thread later, an update: Mixed chimerism was the undoing of my daughter's BMT. "Something" (we will never know what) riled up her immune system, and her original cells spent 2013 in a repeat of 2010....slowly destroying her bone marrow. Her cells won, and her sister's cells lost.

She was retransplanted in Nov 2013 with the same sibling donor, but a harsher conditioning to destroy more recipient cells. A few bumps in the road, but moving along in her recovery. It was a little surreal to repeat the whole business, but the writing was on the wall.
__________________
Connie, Mother of AA daughter (age 21) MSD BMT 8/2010; struggling with dropping blood counts in 2013 after 2 great years. Second BMT 11/4/13.
Reply With Quote
  #4  
Old Tue Jul 29, 2014, 06:11 PM
Whizbang Whizbang is offline
Member
 
Join Date: Aug 2013
Location: Central NJ
Posts: 299
AAMarge,

I had the harshest conditioning possible (including TBI), due to my high risk MDS and terrible cytogenetics... It was quite impossible for me to revert due to chimerism, yet 8 months after my transplant my MDS transformed to RBC leukemia, still 100% donor...

I'm 23 days out from my (7+3) chemo, waiting for my counts to come back, and moving forward with the same sibling donor also... I agree it's crazy going through a 2nd Transplant (scheduled for 8/31/14), the Brightside being - knowing what to expect... And the fact that we were lucky enough to be able to handle and have a second transplant...

I wish you and your daughter continued success, and a permanent remission...

All the Best, and may God Bless us ALL!!!
David
__________________
Married, father of three daughters; now 46; diagnosed w/ Major form MDS 6/18/2013; had low counts across the board; Multiple chromosome abnormalities; Finished 2nd round Dacogen 9/13; SCT - Oct. 31, 2013; Sibling match 10/10 ; 5.5% blasts down to 3%, now 1% (post BMT)
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
+ 63 Days: Mixed Chimerism and Cyclosporine dose pdiitdelhi0204 Transplants 0 Tue Sep 2, 2014 11:06 PM
Mixed Chimerism and Stoping Cyclosporine level-Post transplant pdiitdelhi0204 Transplants 1 Sat Aug 9, 2014 04:25 PM
Understaning mixed chimerism????? pdiitdelhi0204 Transplants 0 Sat Aug 9, 2014 03:01 PM
Questions to ASK at BMT Consult NLJabbari Transplants 4 Tue Oct 29, 2013 09:51 PM
Update on BMT of 14th Feb 2007 Nina van Nunen Transplants 4 Mon May 28, 2007 03:59 PM


All times are GMT -4. The time now is 12:48 AM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2018, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright 2006-2018 Marrowforums.org