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Old Tue Nov 14, 2017, 06:32 PM
lacanada1 lacanada1 is offline
Join Date: Apr 2008
Location: London, UK
Posts: 16
RUNX1 gene

Has anyone ever come across the RUNX1 gene? Testing for it, both in the blood and skin biopsy. My docs here in London seem interested in it and have done it to me recently and just curious if anyone has any insight?
37/M. Feb 2008 Dx hypoplastic anemia. Watch and wait until Jan 2012, dx with hypoplastic MDS (RCMD). Sep 2012 ATG, on cyclo since. Partial remission, living very active life.
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Old Tue Nov 14, 2017, 07:09 PM
Neil Cuadra Neil Cuadra is offline
Join Date: Jul 2006
Location: Los Angeles, California
Posts: 2,473

If you search for "RUNX1" on the search page you'll find a number of other threads that mention it.
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Old Tue Nov 14, 2017, 08:28 PM
Data Data is offline
Join Date: Sep 2014
Location: Florida
Posts: 245

The following is from the web site:

RUNX1 is a transcription factor that forms a complex with the cofactor CBFB. This complex provides stability to the RUNX1 protein which is involved in the generation of hematopoietic stem cells and for their differentiation into myeloid and lymphoid lines. Loss of RUNX1 function has been shown to impair differentiation between myeloid and lymphoid lines often resulting in the development of leukemia.

Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
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Old Wed Nov 15, 2017, 05:16 AM
lisa3112 lisa3112 is offline
Join Date: Jun 2016
Location: Melbourne
Posts: 104
Hey, I had runx1 prior to my stem cell transplant. It predisposes you to getting forms of cancer apparently. They have a new test in Australia which can pick up very small traces of it in your cells. My doctor wanted to make sure it was gone post transplant. Hope that helps 😊
Now 30yr old. Diagnosed AML dec 2015 (Most likely MDS prior). Trisomy 6. Runx1 mutation also. Had induction and consolidation chemo. Marrow failure ++ so SCT on 21st of March with MUD. Married with a 1yr old!
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