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Transplants Bone marrow and stem cell transplantation

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Old Wed Jun 22, 2016, 06:38 PM
Data Data is offline
Join Date: Sep 2014
Location: Florida
Posts: 245
Thumbs up Interesting Article

I ran across this article and thought it was interesting. Granted it is a small study (519 patients).


Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.

Last edited by Data : Thu Jun 23, 2016 at 03:27 PM.
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Old Wed Jun 22, 2016, 07:17 PM
Neil Cuadra Neil Cuadra is offline
Join Date: Jul 2006
Location: Los Angeles, California
Posts: 2,501

This looks like an excellent in-depth study of transplant outcomes and the factors that can predict success or failure.

In addition to the IPSS-R scoring system, they looked at a classification called monsomal karyotype (MK), which means that the patient has either
  • multiple chromosomes that are missing 1 of its pair.
  • one chromosome that is missing 1 of its pair AND a structural abnormality.
They found that IPSS-R was a good predictor of transplant outcomes, except that MK patients had a far worse expected outcome.

They also found that HGB < 8 was a better evaluative cutoff than HGB < 10 for classifying a patient's anemia.
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