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#1
Sun Oct 6, 2013, 01:56 PM
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sotatercept, ace 536
Is anyone on the forum aware of the trials going on for ace 536 or sotatercept? My initial thought reading the article is that it specifically targets Anemia in mDS patients.
http://www.clinicaltrials.gov/ct2/sh...tercept&rank=7
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Father 72, diagnosed MDS RCMD June 2011. HGB 5.5, WBC 7.2, Plt 400 Cytogenetics Normal. Blast cell count 2% ( July 2012 ). Currently on Danazol, Ferritin 750 
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#2
Sun Oct 6, 2013, 03:38 PM
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Sotatercept
Hi vikasgoyal,
Very interesting study with patients from many centers in the US and France. Kind regards Birgitta-A
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#3
Sun Oct 6, 2013, 05:05 PM
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From an earlier thread on ACE-536 (Feb.2013)
...There's still more to do but these are very encouraging words in the PR...
 "In a phase 1 clinical study of healthy volunteers, ACE-536 produced a dose-dependent increase in red blood cells and hemoglobin levels. " http://www.checkorphan.org/grid/news...stic-syndromes
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Ric: Low-risk MDS (blasts <4%); 4 cycles Revlimid no positive response; PRBC transfusion dependent; so far, 392'units' over 8 3/4 years; BMB #4 (15/04/01) shows evolution to AML (blasts 20-30%  ) 47,XY,del(5) (q22q35),+21[24][cp24]/46,XY(1).
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