Home         Forums  

Go Back   Marrowforums > Treatments > Transfusions and Iron Overload
Register FAQ Search Today's Posts Mark Forums Read

Transfusions and Iron Overload Blood and platelet transfusions, iron testing and treatments

Reply
 
Thread Tools Search this Thread
  #1  
Old Mon Mar 1, 2010, 04:15 PM
Big Bruin Big Bruin is offline
Member
 
Join Date: Mar 2010
Posts: 5
Iron Overload from Transfusions ever lead to Hemachromatosis?

Hi - New guy here!

I was treated for severe Aplastic Anemia at the NIH in Feb. 2007... Rabbit ATG, followed by 6 months of fairly heavy Cyclosporine. Countless platelet transfusions, and perhaps 30-50 bags of red blood over that period.

No transfusions of any kind since August 2007.

In early 2009, they decided I was healthy enough to start stripping out the excess iron with phlebotomies, and I did one every other month.

I started out with a ferritin level near 2800, and it came down with each of the first 5 phlebotomies... Something like 2400, 1800, 1100, 900, 700...

A few weeks after the 6th phlebotomy we checked the level and it was back up to 1189. Checked again three weeks later and it was the same.

Seems odd to have a spike like that... and not enough time has passed to have a sense if this is an upward trend, or just some fluke.

Anyway - they are now doing Hemachromatosis / HFE gene testing. ANyne ever get diagnosed with Hemachromatosis after transfusions? Would it suggest I may have had it or was susceptible to it previously?

Doesn't change much no matter what the results are... I am back on the phlebotomies in a few weeks, btu I was just curious if anyone else has something like this.

Thanks!
Reply With Quote
  #2  
Old Mon Mar 1, 2010, 05:28 PM
Marlene Marlene is offline
Member
 
Join Date: Oct 2006
Location: Springfield, VA
Posts: 1,406
John doesn't have hemachomatosis but we were told that if you have it, it may not show up til later in life.

Even after you get your FE down from phlebotomies, I think your body will still pull iron that's stored in your organs and bind to the circulating FE protein like it's supposed to do. Which means you may see your FE rise after you thought you got it all out. This is just my opinion though.

It's good they're doing the gene testing.
__________________
Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
Reply With Quote
  #3  
Old Mon Mar 1, 2010, 09:02 PM
Big Bruin Big Bruin is offline
Member
 
Join Date: Mar 2010
Posts: 5
Thanks Marlene - I was wondering if it was possible for some to have settled and that it might be able to get back into my blood stream. I forget the exact analogy my Dad made, but it was something like a mud puddle being clear until you stomp in it...
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
ASH 2010 Highly Transfused MDS Patients Often Have Cardiac Iron Overload akita Transfusions and Iron Overload 0 Wed Dec 15, 2010 05:21 PM
ASH 2010 Iron Overload results in deficient Hematopoiesis akita Transfusions and Iron Overload 0 Sat Dec 11, 2010 04:43 PM
ASH 2010 Iron Overload Accelerates Development of Leukaemia - Mouse Model akita Transfusions and Iron Overload 0 Sat Dec 11, 2010 04:21 PM
Iron Overload following Blood transfusions towncarlady Transfusions and Iron Overload 19 Fri Feb 12, 2010 02:52 AM
Iron Overload, Liver and Heart Function Francine S Transfusions and Iron Overload 7 Mon Jun 1, 2009 01:01 PM


All times are GMT -4. The time now is 11:01 AM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright © 2006-2020 Marrowforums.org