Home         Forums  

Go Back   Marrowforums > Treatments > Drugs and Drug Treatments
Register FAQ Search Today's Posts Mark Forums Read

Drugs and Drug Treatments ATG, Cyclosporine, Revlimid, Vidaza, Dacogen, ...

Reply
 
Thread Tools Search this Thread
  #1  
Old Thu Mar 27, 2008, 03:47 PM
Birgitta-A Birgitta-A is offline
Member
 
Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918
Which patients will respond to Revlimid ?

Lenalidomid responders
Recently, researchers have discovered that some people with MDS respond very well to a drug called lenalidomide. Three-quarters of patients whose MDS is characterized by the loss of a small part of Chromosome 5 need fewer blood transfusions after being given lenalidomide but only a quarter of people without this chromosomal defect respond to the drug.

Unfortunately, most patients with MDS do not have this chromosome abnormality and there is no way to predict which of these patients are likely to respond to lenalidomide. Lenalidomide is a toxic drug that damages white blood cells and platelets, so it is important not to give it to people who might not benefit.

In this study, the researchers have used gene expression profiling (a technique that catalogs all the genes expressed by a cell) to try to develop a way of predicting who will respond to lenalidomide...

...The erythroid specificity of the lenalidomide response signature is consistent with the biology of the 5q− syndrome in MDS. Patients with the 5q− syndrome have a severe anemia, a normal or elevated platelet count, and a relatively preserved neutrophil count.

The gene or genes on Chromosome 5q that block erythroid differentiation have not been identified. Our gene expression data indicate that lenalidomideā€“responsive MDS patients lacking 5q deletions have a defect in erythroid differentiation analogous to the ineffective erythropoiesis in patients with 5q deletions, indicating a possible commonality in the molecular basis of MDS in patients who respond to lenalidomide...

http://medicine.plosjournals.org/per...l.pmed.0050035
Kind regards
Birgitta-A
69 yo, MDS Interm-1 dx May 2006, transfusion dependent, Desferal 4 days every 6:th week with transfusion, Neupogen 2 injections/week
Reply With Quote
  #2  
Old Tue Apr 29, 2008, 09:51 PM
GENERAL GENERAL is offline
Member
 
Join Date: Apr 2008
Location: PENNSAUKEN NEW JERSEY
Posts: 2
Smile Revlimid Patients





I HAVE AML AND I AM ON REVLIMID THE DOSE IS 5mg. IS ANY ONE ON THIS AND HOW ARE THEY MAKING OUT?
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Vitamin K-2 lfeinsmith MDS 42 Tue Nov 29, 2016 07:04 PM
One-day Patient and Family Forum in Los Angeles, California, February 27, 2016 Marrowforums News and Events 2 Sat Feb 27, 2016 09:05 PM
Revlimid for non del5q MDS patients Birgitta-A Drugs and Drug Treatments 1 Wed Dec 10, 2014 12:29 PM
New Oral Medication Gives Hope to Patients with Blood Cancer Doug Mylie Canada 0 Sat Mar 8, 2008 12:27 PM


All times are GMT -4. The time now is 06:28 AM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright Ā© 2006-2020 Marrowforums.org