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PNH Paroxysmal nocturnal hemoglobinuria

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Old Sat Dec 9, 2017, 10:34 PM
Sarah W Sarah W is offline
Join Date: Sep 2013
Location: Kansas City
Posts: 5
Megakaryocytic hypoplasia

My bone marrow biopsy last month included a diagnosis of Megakaryocytic Hypoplasia. Anyone else with PNH have this and if so, did your hematologist treat it with any particular medicine?
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Old Mon Dec 11, 2017, 09:55 AM
Hopeful Hopeful is offline
Join Date: Jan 2009
Location: California, USA
Posts: 668
Hi Sarah,

Megakaryocytic Hypoplasia refers to a decrease in the number/development of your platelet precursor cells.

This result can't be interpreted in isolation. It could be due to a recent virus or medication. It also is seen in aplastic anemia.
50 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. Tried slow cyclosporine taper over 4+ years. Platelets fell, so back on cyclosporine. Trisomy 6 clone in 5% of cells.
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