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Clinical Trials Considering or participating in research studies

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  #1  
Old Sun Mar 18, 2007, 09:35 AM
Barbara2007 Barbara2007 is offline
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Pilot study of Alemtuzumab (Campath) at NIH

i have severe aplastic anemia-originally treated w/ATG (horse) in Nov.03. I am blood and platlet dependent weekly. i was not responding and the prograf was damaging my kidneys.My Dr. reccommended this trial. This particular research protocol was selected bcause I had received prior immunosuppressive therapy and had failed to respond or my diseaSE had returned following immunosupressive treatment. On Nov. 1st I was admitted to the Natl. Inst. of Health in Bethesda, MD. I had initially been screened w/blood tests, bone marrow biopsy and echcardiogram. At admission-I wore a 24 hr. holter monitor,another chest x-ray and EKG. The Campath was admisistered IV-the first initial dose was small and I reacted w/chills,fever and shakes. The nurses were right on it w/demorel and nice warm blankets.Iwas given magnesium IV-mine was low.Everything was closely monitored. i reacted for the first 3-4 days with chills, shakes, and fever but it was quickly stabilized. The staff there are the most compassionate,caring and optimistic folks. I was put on a 1800 calorie diet and w/every meal I ordered (I was trying to be good-honest! she would tell me if I was over my allotted calories- it got to be like food bingo! I went home after 10 days wearing the 24 hr. holter moniter again and then mailed it back. i sent tubes of blood to them on a regular basis-they provided the vials, canisters and mailing tubes and labels. I now send blood monthly. I went back for a 3 month check up and the same stuff was repeated (not the biopsy) No change really-I knew my counts had not yet responded. A few days after comig home after my initial treatment-I started to not feel very well-I thought my sugar was down-but I was dizzy,felt faint and my bones ached so much I could not get comfortable.The chills and fever came and I went to the ER and was admitted immediately and put on triple antibiotics and morphine drip. I was in there for a week. I was discharged wcounts of WBC-0.3, hgb-9, platlets-19, My platlets have continued to drop and now remain at 2-3 and my ANC at 100. I go to NIH again in May for the bone marow biopsy and I pray there is growth, If not the Dr. there said there would be something else they would try. I would go to clinical trials again there-there is hope, compassion, and so much education. Who knows? These trials may find a cure! i now receive aerosolized pentemidine monthly and take Valacyclovir (500mg) daily, cipro (500mg) twice daily along w/ambien, glipizide (diabeties Type II upon AA) and nexium and neurontin (600mg) for the neuropathy in my feet from case serum reaction to ATG. And my creatinine levels are back to normal. Has anyone else had this therapy?
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  #2  
Old Sat Sep 22, 2007, 04:18 PM
Susan Susan is offline
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Barbara,

How are you feeling? IThat sounds miserable. I hope the Campath did not set you back for more than a short period. Thanks for sharing, so others know what might happen with themselves on this trial. I don't think I want to try that trial

Dr Maciejewski at Clevleand Clinic and head of the Bone Marrow Failure Consortium once mentioned to me that if ATG and Cyclo ever failed we could try Zenapax. Dr "Mac" is a wonderful person and trained under Neal Young at NIH.
I think it would be worth it to consult with him if your counts are still looking severely low.

Best Wishes,
suz
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  #3  
Old Thu Jul 15, 2010, 07:08 AM
Lisa Z Lisa Z is offline
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Barbara,
I did the Campath Trial in March of 2010. My only adverse reactions were the rigors you describe. Otherwise, I tolerated it OK. It took me a while for my counts to come up. It took almost 6 months. I got impatient towards the end and had 4 injections of Aranesp to help the red counts, but in retrospect, I think they would have come up by themselves. I havent' had any growth factors since Oct. 09 and no transfusions since June of 09.
I also take Valtrex and Pentamidine as my CD4 counts have remained low.
At my 1 year follow up, which was March 2010, they said blood was OK, but my thyroid got screwed up due to the Campath, so now I am on thyroid meds. Is our thyroid OK?
My cytogenics were normal. My counts are all still below normal, but my body has adjusted and I function pretty normally at these levels. (hemo usually around 8.5, but now is 9.6..... curisous to see where this is going...- plt have responded very well and now around 100 , from 40-50, and wbc around 2.3.
I'm glad my lycocytes remain low, as that is what was supressed. My ANC is good enough not to need the Cipro.
Would love to hear back from you.
Lisa
lzieske@verizon.net
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Old Tue Jul 20, 2010, 11:10 PM
Lisa Z Lisa Z is offline
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Hi Barbara-

I'd love to hear from others who did this trial. When did you do it? I guess fairly recently, if you're still sending back the vials. I was also very impressed with the level of care while at NIH. It made me nervous, though, when I left.... it was like going from a cocoon environment to "normal" life and I was totally freaked out about getting an infection. I never did........

Have you talked to others on the trial ever?
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  #5  
Old Sun Jan 1, 2012, 08:28 PM
Susan Susan is offline
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If you're considering trying Campath, plse ignore my old comment above. I didn't know enough about it then. It sounds quite promising and for sure I'd rather do Campath than ATG/CSA. Wish could try as first line treatment for SAA.
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  #6  
Old Wed Apr 7, 2021, 01:41 AM
JoGarbe JoGarbe is offline
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Campath Distribution Program

This thread hasn't been active for awhile, but wondering if there are still people being treated with campath / alemtuzumab. I have a local doctor working with the Cleveland Clinic. I was given a link to access campath, but wondering how others have secured this medication.

Current information takes some searching...

https://www.healthline.com/health-ne...-trials-010814
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Old Wed Apr 7, 2021, 12:59 PM
Neil Cuadra Neil Cuadra is offline
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Quote:
Originally Posted by JoGarbe View Post
This thread hasn't been active for awhile, but wondering if there are still people being treated with campath / alemtuzumab. I have a local doctor working with the Cleveland Clinic. I was given a link to access campath, but wondering how others have secured this medication.

Current information takes some searching...

https://www.healthline.com/health-ne...-trials-010814
Many news sites (example) reported that Sanofi withdrew Campath from the market in 2012. There are still clinical trials involving alemtuzumab in the recruiting phase (example), but I don't know the status for its current use with bone marrow failure diseases like severe aplastic anemia. It's telling that the campath.com website is gone.

Sanofi has an assistance program for patients who have been prescribed Lemtrade, their newer version of alemtuzumab, used to treat multiple sclerosis. Ironically, aplastic anemia is listed as a possible side effect of Lemtrade when used to treat MS.

I suggest trying the Aplastic Anemia & MDS International Foundation's Patient HelpLine, to see if they have information about this.
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  #8  
Old Sat Apr 30, 2022, 01:14 PM
Matthew42 Matthew42 is offline
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Quote:
Originally Posted by Neil Cuadra View Post
Many news sites (example) reported that Sanofi withdrew Campath from the market in 2012. There are still clinical trials involving alemtuzumab in the recruiting phase (example), but I don't know the status for its current use with bone marrow failure diseases like severe aplastic anemia. It's telling that the campath.com website is gone.

Sanofi has an assistance program for patients who have been prescribed Lemtrade, their newer version of alemtuzumab, used to treat multiple sclerosis. Ironically, aplastic anemia is listed as a possible side effect of Lemtrade when used to treat MS.

I suggest trying the Aplastic Anemia & MDS International Foundation's Patient HelpLine, to see if they have information about this.
Hi Neil! I hope you are well.

I just want to say that Dr. Young and his team have recommended Campath for my mother should her aplastic anemia not improve in the next 4-5 months (she had horse-atg many months ago). He says her disease is highly autoimmune (immune-mediated). Not all cases of aplastic anemia are equally immune-mediated. If you have the PNH clone, he says, that really makes your aplastic anemia highly autoimmune. Also, not having cytogenetic changes in your bone marrow six months after ATG also can indicate the highly immune-mediated nature of the disease. There might be other reasons, too, but I am not sure of them. He is a top expert in aplastic anemia, as you know.

Dr. Young said no to rabbit-atg for my mother, as he believes Campath is more likely to work. Also, Campath has little risk of causing negative changes within the bone marrow; this is not the case with rabbit-atg.

Please take care.
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Old Wed May 4, 2022, 11:09 PM
Neil Cuadra Neil Cuadra is offline
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Originally Posted by Matthew42 View Post
Dr. Young said no to rabbit-atg for my mother, as he believes Campath is more likely to work. Also, Campath has little risk of causing negative changes within the bone marrow; this is not the case with rabbit-atg.
I hadn't read about the higher chances of negative bone marrow effects with rabbit ATG. Good to know.

In the past, after a non-response to horse ATG, doctors often weighed the choice between a second round of horse or a first round of rabbit. Campath offers another alternative, and perhaps the preferred choice in many cases, as for your mother.
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  #10  
Old Thu May 5, 2022, 12:38 AM
Matthew42 Matthew42 is offline
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Originally Posted by Neil Cuadra View Post
I hadn't read about the higher chances of negative bone marrow effects with rabbit ATG. Good to know.

In the past, after a non-response to horse ATG, doctors often weighed the choice between a second round of horse or a first round of rabbit. Campath offers another alternative, and perhaps the preferred choice in many cases, as for your mother.
Campath is used to treat MS and other autoimmune diseases. Dr. Young says it works similarly to ATG, but yet very differently. Rabbit-atg is just a stronger version of horse-atg. He prefers to use something "different", as he thinks it is much more likely to work. He is just not keen on rabbit-atg for my mother.

Remember - we're just being told this info by another hematologist who consults with Dr. Young.

Yes, repeating atg (rabbit or horse) poses a risk of negative bone marrow effects (cytogenetic changes, etc.). Campath does not. That's what I understand.

By the way, my mother's hematologist consulted a second doctor at the NIH, and she recommended Campath, too.

We're also now considering the possibility of high-dose Cytoxan, as recommended by Dr. Brodsky, another expert in aplastic anemia. He has his own take on the matter, but that's why you consider second/third opinions, etc.

But that's it: Campath, or Cytoxan.
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