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Clinical Trials Considering or participating in research studies

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Old Sun Oct 6, 2013, 01:56 PM
vikasgoyal vikasgoyal is offline
Join Date: May 2012
Location: nashville,TN
Posts: 58
sotatercept, ace 536

Is anyone on the forum aware of the trials going on for ace 536 or sotatercept? My initial thought reading the article is that it specifically targets Anemia in mDS patients.

Father 72, diagnosed MDS RCMD June 2011. HGB 5.5, WBC 7.2, Plt 400 Cytogenetics Normal. Blast cell count 2% ( July 2012 ). Currently on Danazol, Ferritin 750
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Old Sun Oct 6, 2013, 03:38 PM
Birgitta-A Birgitta-A is offline
Join Date: Oct 2007
Location: Stockholm, Sweden
Posts: 1,918

Hi vikasgoyal,
Very interesting study with patients from many centers in the US and France.
Kind regards
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Old Sun Oct 6, 2013, 05:05 PM
riccd2001 riccd2001 is offline
Join Date: Aug 2010
Location: Burlington,Ontario,Canada
Posts: 186
From an earlier thread on ACE-536 (Feb.2013)

...There's still more to do but these are very encouraging words in the PR...

"In a phase 1 clinical study of healthy volunteers, ACE-536 produced a dose-dependent increase in red blood cells and hemoglobin levels. "

Ric: Low-risk MDS (blasts <4%); 4 cycles Revlimid no positive response; PRBC transfusion dependent; so far, 392'units' over 8 3/4 years; BMB #4 (15/04/01) shows evolution to AML (blasts 20-30%) 47,XY,del(5) (q22q35),+21[24][cp24]/46,XY(1).
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