Home         Forums  

Go Back   Marrowforums > Bone Marrow Failure Diseases > AA
Register FAQ Search Today's Posts Mark Forums Read

AA Aplastic anemia

Reply
 
Thread Tools Search this Thread
  #1  
Old Mon Jul 29, 2013, 03:23 PM
Kobi_M Kobi_M is offline
Member
 
Join Date: Jul 2013
Location: Israel, Haifa
Posts: 1
BMT after relapse

Hi! Last year I diagnosed with severe Aplastic Anemia. I had ATG combine with Cyclosporine with excellent respone and normal blood count after only two weeks!!! two month ago I had a relapse due to the tapering of the cyclosporine. I have unrealated match donor and the doctor said we should go for BMT and not repeat the ATG course. I can't decide what to do, the immunosuppressive therapy went so good last time and I think I should repeat that therapy without tappering the Cyclosporine

what do you suggest??
thanks, Kobi
Reply With Quote
  #2  
Old Mon Jul 29, 2013, 10:03 PM
Hopeful Hopeful is offline
Member
 
Join Date: Jan 2009
Location: California, USA
Posts: 682
If it were me, and it was too late to turn things around with cyclosporine alone, I would repeat the ATG with cyclosporine but extend the cyclosporine to 6 - 12 months before beginning a very very slow taper. This is assuming your counts rebound quickly again.

I would only consider the BMT if this approach failed.
__________________
52 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. Tried slow cyclosporine taper over 4+ years. Platelets fell, so back on cyclosporine. Trisomy 6 clone in 5% of cells.
Reply With Quote
  #3  
Old Tue Jul 30, 2013, 03:00 PM
curlygirl curlygirl is offline
Member
 
Join Date: Jun 2013
Posts: 151
I think a lot depends on your age and how many matches you have. My son just had ATG so it is too early to tell if it is work. He is 8 and is lucky to have a lot of perfect matches on our bone marrow registry but I think that just makes them more anxious to do it. They're already talking about doing it if this doesn't work. Sort of like "oh, the matches are out there, it's a shame to waste them." I think I'd rather go for a second round of ATG and see if that works. Hopefully my son will recover nicely on this round of ATG and it will be a moot point. I do think Drs. sometimes talk about it like it's not a big deal but with 35-40% of recipients getting chronic graft-vs.-host disease (GVHD) I feel like it still is. Also, you get cyclosporine after the transplant to prevent GVHD so there is still a chance that you'd be on it long term anyway. It's a hard decision. Good luck!
Reply With Quote
  #4  
Old Wed Jul 31, 2013, 06:34 AM
edithr edithr is offline
Member
 
Join Date: Feb 2011
Location: 30 mi West of Cleveland
Posts: 86
I think I would get a second opinion, the BMT seems a bit early given that you had a good response to ATG the first time.

In any case, I wish you well!
__________________
Edith, mom to Eric, dx 2/11 at age 15 with SAA, began ATG/CsA 3/11, switched to Tacrolimis 8/11, off all meds 9/11 and is now considered to have bone marrow failure not otherwise specified.
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Questions to ASK at BMT Consult NLJabbari Transplants 4 Tue Oct 29, 2013 09:51 PM
relapse, 2nd ATG, when do they look for BMT match JodyW AA 6 Mon Feb 11, 2013 09:29 PM
exstramedullary isolated relapse after BMT micho Tell Your Story 0 Fri Feb 20, 2009 12:45 AM
BMT Relapse after 10 years Mary D. Questions and Answers 4 Sun Dec 30, 2007 10:03 PM
Update on BMT of 14th Feb 2007 Nina van Nunen Transplants 4 Mon May 28, 2007 03:59 PM


All times are GMT -4. The time now is 05:18 PM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2018, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright 2006-2018 Marrowforums.org