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Old Sun Oct 30, 2011, 03:16 AM
Andrya D Andrya D is offline
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Cellularity Ranges%

I have been told some discrepant information regarding cellularity. On my first BMB, my cellularity was 35%, this was in Dec 2010. My next one, in July 2011, showed 40% cellularity.

My original doctor, that did the biopsy in Dec 2010, said that my cellularity was low. He said normal for a 30 year old should be about 70 (70% cells, 30% fat.)

My transplant doctors, the ones that performed the July 2011 biopsy, said that 35-40% was normal for a 30 year old.

Has anyone been told that their cellularity was normal when it was above 30%? Any insight?
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Andrya D., mother to Kellan (3/22/2011)
Severe Aplastic Anemia (12/2010); MDS (7/2011); PNH (7/2011); BMT (7/27/2011)
www.andrya-survivingaplasticanemia.blogspot.com
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Old Sun Oct 30, 2011, 10:35 AM
mausmish mausmish is offline
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I recall reading somewhere that your cellularity should be roughly 100 minus your age. I just did a quick search and couldn't find the reference but here's another with slightly different info. It is age dependent.

http://www.pathologystudent.com/?p=645
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com

Last edited by mausmish : Sun Oct 30, 2011 at 10:45 AM.
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Old Sun Oct 30, 2011, 05:28 PM
Andrya D Andrya D is offline
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Thanks! I'm going to ask my doctors again about it on Tuesday for my appointment, so I have a better understanding when I get my Day 100 results.
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Andrya D., mother to Kellan (3/22/2011)
Severe Aplastic Anemia (12/2010); MDS (7/2011); PNH (7/2011); BMT (7/27/2011)
www.andrya-survivingaplasticanemia.blogspot.com
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Old Tue Nov 1, 2011, 01:09 PM
Darice Darice is offline
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Question Cellularity question

So what is the preferred direction for cellularity . . . higher or lower than the "norm" for your age? At 70, looks like hubby's cellularity should be around 30% . . . his is 40-50% . . . so he's higher than the norm . . . but is this good or bad?
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hubby 73, dx NHL 2001, CNS involvement. SCT (auto) 5/08 [dx UTUC renal pelvis, 2010/surgeries/MMC], MANY recurrences, chemos, surgeries, rad. dx t-MDS 3/11: IPSS 1.5 (Int-2); MDA 11, RCMD trilineage, inc. Fe, ring sideroblasts, 7q del/mono 7 (51.5%), 46,XY,t(6,17)(p22;q25)[4]/45,XY,-7[4]/46,XY[12].
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Old Tue Nov 1, 2011, 03:54 PM
mausmish mausmish is offline
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That is a good question for your husband's hematologist/oncologist. From general reading, it seems that cellularity is used as a diagnostic/classification tool and in that case, hypocellularity (too few) is separated from hypercellularity/normocelluarity as a group. However, I've read in at least one study that cellularity is not a prognostic indicator in MDS. Let me note that I'm a computer geek, not a medical person, so take anything I say with a grain of salt!
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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Old Wed Nov 2, 2011, 01:16 AM
Neil Cuadra Neil Cuadra is offline
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Quote:
Originally Posted by Darice View Post
So what is the preferred direction for cellularity . . . higher or lower than the "norm" for your age? At 70, looks like hubby's cellularity should be around 30% . . . his is 40-50% . . . so he's higher than the norm . . . but is this good or bad?
Higher than average is good!
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Old Wed Nov 2, 2011, 05:17 PM
Darice Darice is offline
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Nice to get good news every once in a while

I have wondered whether they try to do another BMB periodically to see how things are going . . . not that he wants another one . . . had more than enough of those over the past ten years . . . but how else do you really gauge the progress of the disease? I think we're all surprised that the Neulasta is keeping his HGB & platelets up as well as the WBC and I sure don't want to rock that boat! We'll just keep floating along enjoying the view.
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hubby 73, dx NHL 2001, CNS involvement. SCT (auto) 5/08 [dx UTUC renal pelvis, 2010/surgeries/MMC], MANY recurrences, chemos, surgeries, rad. dx t-MDS 3/11: IPSS 1.5 (Int-2); MDA 11, RCMD trilineage, inc. Fe, ring sideroblasts, 7q del/mono 7 (51.5%), 46,XY,t(6,17)(p22;q25)[4]/45,XY,-7[4]/46,XY[12].
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