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AA Aplastic anemia

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Old Wed May 16, 2018, 09:44 AM
LoreneS LoreneS is offline
Join Date: Dec 2017
Location: Minneapolis
Posts: 3
IST treatment

Hello, first time I have written. Our daughter is almost to the 3 month mark post ATG treatment. The Dr. wants to see some improvement at the 3 month mark as she said that indicates success. Has anyone heard of this? Thanks.
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Old Thu May 17, 2018, 03:05 PM
Marlene Marlene is offline
Join Date: Oct 2006
Location: Springfield, VA
Posts: 1,360
We don't have experience with ATG but many others on this board have. From what I remember from their past posts is that 3 months is a little too soon judge the efficacy of ATG. It can take anywhere from 6 months to a year. Hopefully, others with first hand experience will chime in.
Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of January 2017, FE is 233, HGB 11.7, WBC 5.1/ANC 4.0, Plts 90K.
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Old Sun Jun 24, 2018, 02:14 PM
Hopeful Hopeful is offline
Join Date: Jan 2009
Location: California, USA
Posts: 725
Hi LoreneS,

Sorry to miss your post. How is your daughter doing now? Do you see any improvement in any of her blood counts, even if it is only increased time between transfusions?
53 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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Old Mon Jun 25, 2018, 06:04 PM
evansmom evansmom is offline
Join Date: Nov 2007
Location: Ontario, Canada
Posts: 203
Three months can be somewhat on the early side to see any response. The norm is around six months, but the comfort level of waiting and watching for that length of time or longer mostly depends on how low the ANC is sitting. If the ANC is consistently higher than 500, it's a bit less concerning waiting it out whereas if the ANC is below 500, the risk of serious infection, especially a fungal one, makes it necessary to prepare for BMT sooner rather than later.
Nicole, mom to Evan (20); diagnosed SAA November 2007, hATG mid-November 2007, no response after 6 months, unrelated 9/10 BMT June 2008, no GVH, health completely restored thanks to our beloved donor Bryan from Tennessee.

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