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Transplants Bone marrow and stem cell transplantation

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  #1  
Old Wed Jan 18, 2012, 07:58 AM
Marlene Marlene is offline
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Use of a natural enzyme...

to treat GVHD is being explored. Looks like they may start trials for those with GVHD where conventional treatment has failed. It appears to have few side effects and does not suppress the immune system.

http://www.sciencedaily.com/releases...0117144224.htm
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
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Old Wed Jan 18, 2012, 11:24 AM
DanL DanL is offline
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i think that in retrospect this sounds like a no duh trial. alpha 1 antitrypsin is responsible for protecting the lung and liver, which are 2 major gvhd sites. it protects them by reducing inflammation. i would hope this makes its way to tria
l quickly since there is a reasonable track record and history in copd patients with low alpha 1 levels
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MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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Old Wed Jan 18, 2012, 12:54 PM
Marlene Marlene is offline
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Thank for the insights on this enzyme. I looked a bit further and found that it's used to treat genetic disorder where the liver cannot release what it manufactures it into the bloodstream causing a deficiency in it. Thereby, causing lung and liver problems. It's used to treat lung problems in these individuals. It's a once weekly IV infusion. The enzyme is derived from pooled blood plasma.

And since it is already being used in humans, I too think it's a "no-brainer" to move forward. I guess all they need is $$$$ and some patients. What's difficult though is that the patient has had to fail all other conventional therapies. And since it's not a drug, funding may be difficult to get.
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
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