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#1
Tue Jan 11, 2022, 01:24 PM
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Report on study to reduce chronic GVHD
New graft strategy may improve outcomes for blood stem cell recipients
https://www.sciencedaily.com/release...0110184837.htm
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K. 
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#2
Tue Jan 11, 2022, 02:23 PM
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The results are quite impressive, with a huge reduction in GVHD.
It's been known for a while that removing T cells could reduce GVHD. The problem was that it also increased infection and relapse rates. The key to this new strategy is to remove only certain T cells, and that seems to make a large difference. Let's hope the method shows such great results in the randomized trials yet to come!
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Founder of Marrowforums and caregiver for my wife
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