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MDS Myelodysplastic syndromes

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Old Sun Sep 7, 2014, 05:23 PM
MikeE07 MikeE07 is offline
Join Date: Sep 2014
Posts: 1
Bone Marrow Results Question

Hello All,

Hoping someone can help me with this question:

In 2010, I was diagnosed with MDS (RAEB-2) with 19-20% blasts. Upon presentation, my bone marrow was characterized as hypercellular (approx. 61% cellularity). In 2013, a repeat bone marrow biopsy classified the bone marrow as normocellular (approx. 40% cellularity) with 25% blasts. While a bone marrow biopsy, in 2014, categorized the marrow as hypo cellular (approx 29% cellularity) with 40-50% blasts. What would cause an initially hyper cellular bone marrow to become hypo cellular? If relevant, the 2014 bone marrow biopsy was conducted during an active infection.

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Old Sun Sep 7, 2014, 09:03 PM
amyangel amyangel is offline
Join Date: Jun 2014
Location: Wisconsin
Posts: 64
Wow ! sorry to hear how many blasts you have in 2014 not tomention all the other years too ,

my daughter had her BMB done in Feb. you I thought the something she was so septic and had so many infection I thought hoe could you even get a good biopsy done ???

Her hematologist thought the something too, but yet she knew she knew it was still going to come back MDS and she repeated the BMB after my daughter wasn't septic anymore and it just didn't matter it still showed up MDS / ALPS with fibrosis

prayers to you
Mother of a daughter 27 with MDS . Cognitively delayed at birth 1987 , seizures 5 days old . pancytopenia 2006, AIHA 2013, EVANS 2013 , CVID 2013, ALPS 2014. MDS 2014
WBC .3 , hemoglobin 7.3 , hematocrit 2, platelets 60 , neutrophil .21 Mag 1.6, Potassium 4.6
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Old Mon Sep 8, 2014, 04:09 PM
katgio50 katgio50 is offline
Join Date: May 2012
Location: Venice,FL
Posts: 34
I am very confused about the number of blasts that you mentioned. I thought that anything over 20% was considered acute myeloid leukemia. Am I missing something here?
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