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MDS Myelodysplastic syndromes

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Old Tue Apr 16, 2013, 06:55 AM
Pdaw Pdaw is offline
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Location: Eastbourne
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Bone Marrow Result - definitions?

Hi - I finally have managed to obtain a copy of my BMB report.

The abnormalities mentioned are;
  • "Some megakaryocytes appear hypolobulated. There are multiple interstitial aggregates composed of small lymphoid cells and a diffuse population of small lymphocytes throughout the marrow. The reticulin is increased in these aggregates (WHO grade 1) but not elsewhere.
  • ....the lymphoid cells are strongly positive for BCL2 (could be the numerous T cells).......Ki67 positive proliferation index <5%.
  • CD61 confirms there is an element of dysmegakaryopoiesis with scattered small and hypobulated forms p53 is 5% and weak (modified quick score 3)"

    Final Report
  • "The features are those of bone marrow with lymphoid aggregates which appear to be benign. There is mild dysmegakaryopoiesis, insufficient in itself for a diagnosis of MDS - correlation with bone marrow aspirate is required."

Any thoughts????
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