Home         Forums  

Go Back   Marrowforums > Treatments > Transfusions and Iron Overload
Register FAQ Search Today's Posts Mark Forums Read

Transfusions and Iron Overload Blood and platelet transfusions, iron testing and treatments

Reply
 
Thread Tools Search this Thread
  #1  
Old Fri Dec 10, 2010, 04:14 PM
akita akita is offline
Member
 
Join Date: Nov 2010
Posts: 110
ASH 2010 Hematologic Responses in MDS Patients - Deferasirox/Exjade

Thanks to Birgittas Link to the abstracts of the ASH 2010 i found a lot of interesting abstracts for "chelation". Maybe is not every abstract interesting for everybody.. Regards, Margarete

---
http://ash.confex.com/ash/2010/webpr...aper28313.html

2912 Hematologic Responses In Myelodysplastic Syndromes (MDS) Patients Treated with Deferasirox: An EPIC Post-Hoc Analysis Using International Working Group (IWG) 2006 Criteria *

Citation: "Improvements in hematologic parameters and/or reductions in transfusion requirements have been associated with iron chelation therapy in transfusion-dependent patients with MDS; however, data has been limited to case reports/small studies"

Now there was a bigger study conducted where 341 iron-overloaded MDS-Patients were enrolled. They were treated with deferasirox.

Citation: "During deferasirox treatment, erythroid responses were observed in 22.6% (63/279) of patients. Median time to response was 113.0 days. Of these erythroid responses, a transfusion reduction-only response with maintenance of Hb level was observed in 10.8% (n=30) of patients, Hb improvement-only response in 10% (n=28) of patients and both transfusion and Hb response observed in 1.8% (n=5) of patients. Platelet and neutrophil responses were observed in 14.0% (n=17) of patients after a median of 169.0 days and 19.6% (n=11) of patients after a median of 226 days, respectively."

"Conclusions: This is the first large study to show that, alongside reducing iron overload, deferasirox may affect hematologic parameters in MDS patients."
__________________
Margarete, 54, living in Vienna, Austria,
MDS/AML M2, diagnosed 9/2007, then Chemos, aSZT 4/2008, chronic GVHD
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Smoking and bone marrow failure lacanada1 Bone Marrow Failure 3 Tue Jan 31, 2012 01:12 PM
ASH 2010 Lenalidomide in MDS with Karyotypes other than del 5q and Refractory to ESAs akita News and Events 0 Thu Dec 16, 2010 02:25 PM
ASH 2010 Splenectomy in Patients with MDS akita MDS 0 Thu Dec 16, 2010 01:46 PM
ASH 2010 Highly Transfused MDS Patients Often Have Cardiac Iron Overload akita Transfusions and Iron Overload 0 Wed Dec 15, 2010 05:21 PM


All times are GMT -4. The time now is 12:32 PM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright © 2006-2020 Marrowforums.org