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Clinical Trials Considering or participating in research studies

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  #1  
Old Wed Dec 21, 2011, 09:55 PM
amberb amberb is offline
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clinical trial

I may have the opportunity to go to NIH to participate in a clinical trial of a medication that helps to bring up platelet counts. The medicine is called Eltrombopag. Has anyone heard about it or been a part of the preliminaries?
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Amber, age 24, diagnosed w/ SAA and treated w/ horse ATG 7/11, rabbit ATG 1/12, on cyclosporine. Started Desferal infusion for iron overload 7/12.
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Old Wed Dec 21, 2011, 10:09 PM
paulaespada paulaespada is offline
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Interrested

Quote:
Originally Posted by amberb View Post
I may have the opportunity to go to NIH to participate in a clinical trial of a medication that helps to bring up platelet counts. The medicine is called Eltrombopag. Has anyone heard about it or been a part of the preliminaries?
Hello!


I'm interrested in know more about this as well.
My husband may be relapsing for the 2nd time, this time with CyA going on...
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Paula Espada - wife of Jorge Espada, diagnosed AA in June 2008, ATG, cyclosporine until Janury 2010, relapse and 2nd ATG June 2010
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  #3  
Old Wed Dec 21, 2011, 10:37 PM
Greg H Greg H is offline
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Hey Amber & Paula,

Marrowforums member Sally C's husband is in the NIH trial of eltrombopag for MDS. The drug is also called Promacta.

You can read about Sally's husband's experience in this thread. I'm sure she'd be happy to correspond with you about the trial; you could send her a private message.

NIH presented a paper on the eltrombopag trial for SAA at the recent ASH meeting. You can read the abstract here, and you could probably get a copy of the full paper from the docs at NIH.

As I read it, 41% responded to the drug; 32% had platelet responses good enough to make them transfusion independent for eight weeks or more.

Hope that helps.

Take care!

Greg
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Greg, 59, dx MDS RCMD Int-1 03/10, 8+ & Dup1(q21q31). NIH Campath 11/2010. Non-responder. Tiny telomeres. TERT mutation. Danazol at NIH 12/11. TX independent 7/12. Pancreatitis 4/15. 15% blasts 4/16. DX RAEB-2. Beginning Vidaza to prep for MUD STC. Check out my blog at www.greghankins.com
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Old Wed Dec 21, 2011, 10:48 PM
mausmish mausmish is offline
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I don't know anything about this trial but participated in an NIH study - they are super.
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Karen, age 62, dx MDS RAEB-2 1/8/10: pancytopenia WBC 2.7k/Hgb 7.4/Hct 22.1/Plt 19k; complex cytogenetics -3,del(5)(q14q33),-6,+8,+mar,17% blasts. MUD BMT Johns Hopkins 11/30/10. Dx tongue cancer 8/31/12. ok now. blog mausmarrow.com
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Old Thu Dec 22, 2011, 07:33 AM
Sally C Sally C is offline
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Hey Amber and Paula,
Greg is correct. You are more than welcome to contact me regarding Promacta.
My husband was their first guinea pig for the Promacta trial for MDS patients at NIH. He received Campath in the spring of '09 and later cyclosporine - both at NIH. He started Promacta in March, 2011. He had been transfusion dependent since 1/09 for platelets and red cells.
He hasn't had platelets since early summer and only one red cell transfusion in 10/11. They said it might help his red cells also which it evidently has.
Platelets this week were 48,000 - they had been as low as 4,000. Red cells have been holding around 9/10. While to some that isn't setting the world on fire but for him, it is. He is tolerating it very well and feels better than he has since his diagnosis in 12/08. According to protocol we'll go for a bone marrow biopsy in Jan.,2012 but I have to believe things are ok as he is doing so well and feeling so good. Will let you know.
Please feel free to contact me through the forums, e-mail - shcalvert3 @aol.com, or phone - 804-590-2313.
God Bless,
Sally
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