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Old Thu Oct 20, 2016, 06:01 PM
Marlene Marlene is offline
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Amino Acid Valine role in blood production

Interesting article on Valine and how it effects blood stem cells.

https://www.scientificamerican.com/a...A_FB_HLTH_NEWS
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of January 2017, FE is 233, HGB 11.7, WBC 5.1/ANC 4.0, Plts 146K.
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Old Thu Oct 20, 2016, 08:15 PM
Neil Cuadra Neil Cuadra is offline
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Marlene,

Many people have doubted that dietary changes could repair bone marrow stem cell production, but this report indicates that it just might be possible. It it's true, this would be a game-changing development!
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Old Fri Oct 21, 2016, 08:49 AM
Marlene Marlene is offline
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As you can tell by so many of my posts, I have no doubt that there's a strong connection with our food and environment as it relates to our health. But it's a huge challenge to figure it all out. This is a very interesting report and has great potential. Valine is vital to other processes in the body so it will be interesting to see what else would be affected if they used this to deplete bone marrow in prep for transplants.
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of January 2017, FE is 233, HGB 11.7, WBC 5.1/ANC 4.0, Plts 146K.
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Old Fri Oct 21, 2016, 01:15 PM
Hopeful Hopeful is offline
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Interesting article... If you read the article from the perspective of person with a recovering hypocellular marrow, it could point to the importance of a diet higher in protein to increase blood cell production.
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50 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. Tried slow cyclosporine taper over 4+ years. Platelets fell, so back on cyclosporine. Trisomy 6 clone in 5% of cells.
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Old Fri Oct 21, 2016, 01:33 PM
Marlene Marlene is offline
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Yes, I agree with higher protein diet with hypo cellular marrow. In John's case, we saw an overall improvement in his recovery when he modified his diet based on metabolic typing. Depending on your assessment, you're categorized into a high protein or high carb or mix plan and it gives you the guidance on the type of protein best for your type as well the portions of fat/protein/carbs. I did it with him and found it really helped me too.

We also knew of another VSAA patient who was able to reverse her VSAA with just supportive treatments. She initially adopted a vegetarian diet but at one point, her counts stopped improving until she added meat back into her diet. The addition of the animal protein was needed to complete her healing.

It's very much a trial and error process.
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of January 2017, FE is 233, HGB 11.7, WBC 5.1/ANC 4.0, Plts 146K.
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