Home         Forums  

Go Back   Marrowforums > Bone Marrow Failure Diseases > MDS
Register FAQ Search Today's Posts Mark Forums Read

MDS Myelodysplastic syndromes

Reply
 
Thread Tools Search this Thread
  #1  
Old Fri Sep 8, 2017, 04:35 PM
Data Data is offline
Member
 
Join Date: Sep 2014
Location: Florida
Posts: 245
Question Reduced Intensity Conditioning (RIC) vs Myeloablative (MA)

I was under the impression I was going to receive Reduced Intensity Conditioning (RIC) prior to my stem cell transplant. My doctor later told me that I had received Myeloablative (MA) conditioning. From the following does anyone know exactly which I got? I believe the Total Body Irradiation was a total of 5 Gray.

____________________________________________________________
Cytarabine will be given daily through your central venous catheter (IV) continuously for 5 total days. Cyclophosphamide (Cytoxan) willl be given once a day through your catheter (IV) over approximately 2 hours for two (2) consecutive days. Total Body Irradiation (TBI) will be administered once prior to your transplant.
____________________________________________________________

Thanks

Data
__________________
Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
Reply With Quote
  #2  
Old Fri Sep 8, 2017, 06:27 PM
Neil Cuadra Neil Cuadra is offline
Owner
 
Join Date: Jul 2006
Location: Los Angeles, California
Posts: 2,553
Data,

Having only one day of TBI seems to imply that it was RIC, not MA conditioning.

Compare the regimens in this chart from this article and you'll see typical differences. 5 Gray is more than the typical RIC dose, but well below the typical MA dose.

Can you match your treatment to one of the regimens shown?
Reply With Quote
  #3  
Old Fri Sep 8, 2017, 08:23 PM
Data Data is offline
Member
 
Join Date: Sep 2014
Location: Florida
Posts: 245
Nice chart

Neil,
I couldn’t find an exact match in the chart but the Cyclophosphamide (Cy), Cytarabine (ARA-C), and TBI seemed to be used more often in the Myeloablative Regiments. The dosage for the TBI did seem low in my case but then I can’t remember for sure what the dose was. I don’t have any records that state what the dosage was. I do have the records that say it was going to be RIC and what drugs were given to me and for how long. The main reason I got to thinking is was myeloablative was the doctor had said it was on a couple of occasions but I don’t really trust him because he has changed what he said on several occasions.

Thanks again for your comments.

Data
__________________
Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
Reply With Quote
  #4  
Old Sat Sep 9, 2017, 05:05 PM
DanL DanL is offline
Member
 
Join Date: Dec 2010
Location: Denver, CO
Posts: 590
Data,

I reviewed several articles on RIC vs MA and it appears that your dosing levels of ARA-C and CY would be the determining factors. It kind of looks like your doctor split the difference a bit. There are a few studies out of Germany and MD Anderson that used cytarabine as part of RIC.

I did not see anything that matched your regimen exactly though.
__________________
MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
Reply With Quote
  #5  
Old Mon Sep 11, 2017, 04:07 PM
Data Data is offline
Member
 
Join Date: Sep 2014
Location: Florida
Posts: 245
Cool Thanks

Dan,
Thanks for the input. Sorry I haven't replied earlier. We have been busy with Hurricane Irma down here in Florida. Think she is gone now. Good riddance to her and my two ex-wives. Ha Ha.

Datd
__________________
Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
Reply With Quote
  #6  
Old Mon Sep 11, 2017, 04:18 PM
DaveAvl DaveAvl is offline
Member
 
Join Date: Aug 2017
Location: Asheville, NC
Posts: 8
Quote:
Originally Posted by Data View Post
Good riddance to her and my two ex-wives.
Great - now I have images of them both riding bicycles in the tempest, a la The Wizard Of Oz
__________________
Dave age 70, husband of Alan age 67 who was a 25-year HIV survivor and was dx with MDS RAEB-1 5/24/17. Vidaza started 8/7/17. It was ineffective. Passed away 2/7/18.
Reply With Quote
  #7  
Old Tue Sep 12, 2017, 04:04 PM
DanL DanL is offline
Member
 
Join Date: Dec 2010
Location: Denver, CO
Posts: 590
Quote:
Originally Posted by Data View Post
Dan,
Thanks for the input. Sorry I haven't replied earlier. We have been busy with Hurricane Irma down here in Florida. Think she is gone now. Good riddance to her and my two ex-wives. Ha Ha.

Datd

Very glad to hear that you weathered the storm successfully. Hopefully not too much damage to go back to.
__________________
MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
Reply With Quote
  #8  
Old Tue Sep 12, 2017, 06:31 PM
Data Data is offline
Member
 
Join Date: Sep 2014
Location: Florida
Posts: 245
Smile Thanks Dan

Dan,
We never evacuated. I said I would evacuate when it got to a Category 6 (Ha Ha). We only had really small tree limbs break. We lost power for about 8 hours. No Flooding. The refrigerator kept everything cold/frozen. We were very lucky! I feel for those less fortunate.

Thanks again

Data
__________________
Prostate Cancer: Treated in early 2013 with HDR Brachytherapy. MDS-RCMD: Oct 2014. Biopsies: 46,XY,t(7;18)[2]: 46,XY,del(7)( q22)[3]: 45,XY,-7[6]: 45,XY,-7[10]: 45,XY,-7[13]. HSCT in April 2016.
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump


All times are GMT -4. The time now is 12:30 PM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright © 2006-2020 Marrowforums.org