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#1
Sat Mar 28, 2015, 12:42 PM
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Difference between "immature granulocytes" and ...
Does anyone understand the difference between "immature granulocytes" and "peripheral blasts" in blood? Is there a difference? I do know that immature granulocytes are affected by steroids(prenisone), infection and surgery trauma (removal of infection) which mine were. My doctor was very concerned with the high reading of the peripheral blasts (or was it the "immature granulocites") at the time of surgery and had me have a BMB last Tuesday. The immature granulocytes have dropped from .98 (at time of surgery) to .89 to .28 in two weeks time. This is a trend that hopefully will be going back to normal in a short period of time. But, it did trigger an immediate response/alarm from doctor at time of surgery and she was thinking relapse.
Naturally, doctor went on Spring Break with family just after presenting me with the news. I will be seeing her this Monday for my questions. I have been trying to find (if there is any) the difference between the "immature granulocites" which show up on the "Manual Differential" test results and "peripheral blasts" that show up on the blood smear. Is there a difference or is it just different nomenclature? I feel fine.
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age 70, dx RAEB-2 on 11-26-2013 w/11% blasts. 8 cycles Vidaza 3w/Revlimid. SCT 8/15/2014, relapsed@Day+210 (AML). Now(SCT-Day+1005). Prepping w/ 10 days Dacogen for DLI on 6/9/2017. 
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#2
Sat Mar 28, 2015, 01:26 PM
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bailie,
immature granulocytes are any white blood cells that get out of the marrow before maturing. on the differential, they would show up as myelocytea, metamyelocytes, and promyelocytes. blasts usually are counted separately from this grouping of immature granulocytes. igs tend to come out during periods of marrow stress, sometimes from viral infections, drugs, or bone marrow issues. generally they should not be in the peripheral blood, just like blasts. it is probably a good sign that your igs are tending down. hang in there!
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MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD. Neuropathy over 80% of body.
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#3
Sat Mar 28, 2015, 05:31 PM
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Thank you Dan. I guess my desire is that the peripheral blasts react similarly as the immature granulocytes and are a temporary situation from particular influences rather than a relapse.
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age 70, dx RAEB-2 on 11-26-2013 w/11% blasts. 8 cycles Vidaza 3w/Revlimid. SCT 8/15/2014, relapsed@Day+210 (AML). Now(SCT-Day+1005). Prepping w/ 10 days Dacogen for DLI on 6/9/2017.
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#4
Sat Mar 28, 2015, 05:55 PM
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I know many of us were waiting for you to post with your results, Bailie. I don't know much but it does sound good that those numbers are coming down. And what nerve for the physician to go on vacation! I always have to laugh when they do stuff like normal people! It just gives you more time to compose your list of questions.
  Mags
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Margaret, age 68, dx MDS 5 q- 5/09- now RCMD; also MGUS. TP53 and TET2 mutations
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#5
Sat Mar 28, 2015, 11:09 PM
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Phew! That sounds more hopeful, Bailie.
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Dx MDS RAEB 10% blasts + hypogammaglobulinemia, Sep 2011. Jan 2012 BMB - blasts down to 2% w/out treatment so BMT cancelled. Re-diagnosis RCMD. Watch and wait from Feb 2012. IVIg 5-weekly. New diagnosis Oct 2019 AML 23% blasts in marrow, 10% blasts in peripheral blood.
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