Home         Forums  

Go Back   Marrowforums > Treatments > Transfusions and Iron Overload
Register FAQ Search Today's Posts Mark Forums Read

Transfusions and Iron Overload Blood and platelet transfusions, iron testing and treatments

Reply
 
Thread Tools Search this Thread
  #1  
Old Wed Nov 10, 2010, 03:25 PM
Alice P Alice P is offline
Member
 
Join Date: Oct 2010
Location: Maryland
Posts: 28
Vidaza and Blood Transfusions

My husband was diagnosed with MDS in May 2010. He was treated with Aranesp and Neulasta until late August when he started on Vidaza (the Aranesp and Neulasta are also continuing as needed). He had his first red blood cell transfusion in July. He has had 4 more since then, most of which were 4-6 weeks apart. However, 2 weeks ago he had a transfusion that really never seemed to "kick in." He had another yesterday and so far has not felt any improvement. I am wondering if this is part of the suppression that Vidaza causes in the beginning, or is it possible for red blood cell transfusion to quit working? If so, then what??
__________________
Alice, wife of John, diagnosed MDS RAEB-1 5/10. Tried Vidaza, ON 01910.Na (at NIH), & Vidaza + Revlimid with no effect. Progressed to RAEB-2. Supportive care only from 9/2011 until death 1/26/12.
Reply With Quote
  #2  
Old Wed Nov 10, 2010, 04:58 PM
cheri cheri is offline
Member
 
Join Date: Nov 2010
Location: Tuckahoe New Jersey
Posts: 243
Vidaza and Blood Transfusions

Hi Alice
I just finished cycle 3 of Vidaza and am getting transfusions more and more often--2 in the last week! My platelets are not holding at all...yesterday I got 2 units of blood and platelets; more platelets tomorrow.
I am already on irradiated blood and HLA platelets that have to be ordered and come from Phila blood bank.....
I am going to my oncologist tomorrow and hope to get more info....I'll let you know.....
Would love to hear from others, but as they say, everyone is different.
My white count is 1.1; platelets 11, hgb 10 as of today....
Hold on tight and I wish you the best....keep in touch!
__________________
Cheri Age 54; dx Oct 2009 AML, induction chemo only;dx MDS July 2010,- PRBC transfusion dependent; Results BMB 8/4/11--- 6-8% blasts; Danazol 100 mg 3xday; quit Exjade/ GI distress; platelets holding 40's; Fluctuation in blasts in blood--Neupogen 3-4xweek; off Revlimid again! Procrit weekly
Reply With Quote
  #3  
Old Wed Nov 10, 2010, 07:00 PM
ann ann is offline
Member
 
Join Date: Aug 2009
Location: Burleson, TX
Posts: 77
cheri & alice

My husband started Vidaza in August 2009 and it took him a few months to level off. We were really worried for months that the Vidaza wasn't working but it seemed to "kick in" and the transfusions got further and further apart. Now, we are waiting for his 18th round but has been delayed for 2 weeks so far because of low WBC. His platlets and RBC are not good but the white are really low. He got procrit shots bi-weekly after about 9 months into Vidaza treatments. HE got the procrit this week and last week, but its not bringing up his blood counts. Now they are trying a series of four Neuprogen injections. I pray that his counts will go up and he can continue with the Vidaza.
Hang in there ladies, be sure that your oncologists are giving you all the information you need. I will keep you in my prayers.
__________________
Ann, wife of Henry 73 year old diagnosed MDS, congestive heart disease and pulmonary edema..
Reply With Quote
  #4  
Old Wed Nov 10, 2010, 08:17 PM
Alice P Alice P is offline
Member
 
Join Date: Oct 2010
Location: Maryland
Posts: 28
Thanks

Thank you for the replies. I'm new to the forum, and it's helpful to read about others who are going through the same thing. I wish the best to both of you.
__________________
Alice, wife of John, diagnosed MDS RAEB-1 5/10. Tried Vidaza, ON 01910.Na (at NIH), & Vidaza + Revlimid with no effect. Progressed to RAEB-2. Supportive care only from 9/2011 until death 1/26/12.
Reply With Quote
  #5  
Old Wed Nov 10, 2010, 08:56 PM
riccd2001 riccd2001 is offline
Member
 
Join Date: Aug 2010
Location: Burlington,Ontario,Canada
Posts: 186
PRBC Transfusion Effectiveness

Besides the date of blood donation and its expiration date, there is also the variation of actual volume amount which for me has ranged from 238ml to 343ml (a volume difference of 44 per cent is considerable).

Another variable to consider as the number of transfusions and antigens increase is the cross/match process which takes longer to do as well as becoming more difficult to find a donor that is compatible.
__________________
Ric: Low-risk MDS (blasts <4%); 4 cycles Revlimid no positive response; PRBC transfusion dependent; so far, 392'units' over 8 3/4 years; BMB #4 (15/04/01) shows evolution to AML (blasts 20-30%) 47,XY,del(5) (q22q35),+21[24][cp24]/46,XY(1).
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Greg H - Vidaza as a Bridge to Transplant Greg H Transplants 54 Sun May 7, 2017 09:42 PM
Terrible Blood Counts after Vidaza joesmith MDS 11 Tue Aug 12, 2014 03:34 PM
Responding to Vidaza but blood count not increasing Sidhartha MDS 1 Fri Apr 25, 2014 07:30 PM
Vidaza Killing Benefit of Blood Transfusion? Rich D MDS 7 Fri May 25, 2012 10:51 PM
My Fathers story w/ MDS 5q minus lablue MDS 2 Sat Dec 4, 2010 12:18 AM


All times are GMT -4. The time now is 04:32 AM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright © 2006-2020 Marrowforums.org