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#1
Wed Apr 25, 2018, 03:01 PM
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Arthritis drug for GVHD
An investigational drug in clinical trials for rheumatoid arthritis prevents a common, life-threatening side effect of stem cell transplants, new research shows.
https://www.sciencedaily.com/release...0424184126.htm
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K. 
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#2
Wed Apr 25, 2018, 04:31 PM
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It's always interesting when a drug for one disease is found to be useful for other diseases.
They aren't sure how this JAK inhibitors (baricitinib) helps with GVHD, but the article shares one theory: that it keeps donor T cells circulating in the bloodstream and away from vital organs.
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Founder of Marrowforums and caregiver for my wife
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#3
Thu Apr 26, 2018, 11:13 AM
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If memory serves me correctly, Solaris, now used for PNH, was also being developed for RA but failed to treat it. It was a unexpected breakthrough for the treatment of PNH though.
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Marlene, wife to John DX w/SAA April 2002, Stable partial remission; Treated with High Dose Cytoxan, Johns Hopkins, June 2002. Final phlebotomy 11/2016. As of July 2021 HGB 12.0, WBC 4.70/ANC 3.85, Plts 110K.
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