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Old Tue Mar 8, 2011, 02:03 PM
mscrzy1 mscrzy1 is offline
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megaloblasts?

I'm having slighly low counts across the board on my cbc's. My dr. performed 2 biopsies. The first one, they dry tapped about 3 times before finally getting a sample and that sample turned up too hypocellular to make any determinations. The second biopsy they took from my other side and it was cellular. They found an increase in megaloblasts, but my dr. said that they seem to be maturing ok. From what I've read, megaloblasts are described as abnormally large red blood cells that are immature. It is also described as something commonly occuring with those who are B12 or folate deficient, which I have been tested for and shown to have normal amounts of. I'm just a little perplexed by this. Has anyone else come across this?
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Angie

36 yr. old, dx SAA in Jan 1996, treated with ATG in Mar. 1996, off cyclosporine Sept. 1996, last blood transfusion in Aug. 1997, slow decline in counts again November 2010, AA and current count decline thought to be caused by lupus, currently taking 400mg Plaquinil
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Old Wed Mar 9, 2011, 01:07 PM
Hopeful Hopeful is offline
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I've had this noted on my BMB reports as well. I don't know the significance of it but wanted to let you know that you are not alone. I also am not B12 or folate deficient.
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55 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
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