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Old Thu Apr 26, 2018, 02:11 PM
JoMac53 JoMac53 is offline
Join Date: Sep 2017
Posts: 58
Question Cancer ‘vaccine’ eliminates tumors in mice

Hi. I have a question about this... this isn't something that could be done with MDS, right? It sounds to me like it has to be something with a solid tumor? Or am I mis-understanding it?

Cancer ‘vaccine’ eliminates tumors in mice

Activating T cells in tumors eliminated even distant metastases in mice, Stanford researchers found. Lymphoma patients are being recruited to test the technique in a clinical trial.

Joanne, 65F, Primary MDS-EB1, Pancytopenia, 8/17. Weekly CBC, Granix shot if ANC below 1.0.
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Old Fri Apr 27, 2018, 02:09 PM
Neil Cuadra Neil Cuadra is offline
Join Date: Jul 2006
Location: Los Angeles, California
Posts: 2,484
I'd draw the same conclusion you have, that activating T cells isn't going to help with MDS. Giving a boost to the immune system is the opposite of immunosuppression.
Founder of Marrowforums and caregiver for my wife
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Old Fri Apr 27, 2018, 11:11 PM
DanL DanL is offline
Join Date: Dec 2010
Location: Denver, CO
Posts: 559
I would say that this is a little more complicated than yes or no, as MDS is so diverse of a disease. There are some forms that benefit from immune suppression, usually of the trisomy 8 variety, and hypo-mds.

Since there are a couple of components to MDS 1) production of faulty cells and 2) inability of your system to recognize and destroy malfunctioning cells, it is possible that activating T cells could help improve part of the condition.

My thought would be that this would need a combination approach though, as I believe that having the over-active t cell response may cause or increase marrow fibrosis, at least initially.

You would need something that could help the marrow reform - kind of like vidaza does in some cases.

Just my 2 cents - I am not a research biologist or doctor, so it is kind of a Monday morning quarterback approach.

Love the question and research though.
MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. Experiencing autoimmune attack on CNS thought to be GVHD, some gut, skin and ocular cGVHD.
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