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#1
Wed Mar 26, 2014, 05:43 PM
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Flow cytometry - what does this mean?
Does anyone know what the meaning of MYELOBLASTS ARE POSITIVE FOR CD45 (DIM), CD33, CD34, CD117, CD56, HLA-DR, CD13,
CD38, and MPO (partial) on flow cytometry 
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#2
Wed Mar 26, 2014, 10:29 PM
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Your husband is fortunate to have a wife who is so interested in and concerned about his condition.
You will find a little information on surface markers here: http://www.mdsbeacon.com/news/2011/0...ase-prognosis/ Surface marker levels can indicate prognosis. CD34 tends to correlate closely with blast levels but not always. You will need a copy of your husband's biopsy results to see what levels he has. I am interested to know more about surface markers myself and would appreciate knowing where to go to find out.
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Dx MDS RAEB 10% blasts + hypogammaglobulinemia, Sep 2011. Jan 2012 BMB - blasts down to 2% w/out treatment so BMT cancelled. Re-diagnosis RCMD. Watch and wait from Feb 2012. IVIg 5-weekly. New diagnosis Oct 2019 AML 23% blasts in marrow, 10% blasts in peripheral blood.
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#3
Wed Mar 26, 2014, 10:37 PM
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Geez, glad I didn't know this before. My CD34 and CD38 were strongly positive....I never knew what it meant.
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Copper deficiency bone marrow failure (MDS RAEB 1), neuromyelopathy. FISH reported normal cytogenetics but gene testing showed Xq 8.21 mutation Xq19.36 mutation Xq21.40. mutation 1p36. Mutation 15q11.2 deletion
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#4
Wed Mar 26, 2014, 10:44 PM
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Just found I had also saved another link re surface markers. It's quite technical but may be of assistance.
http://www.pathologyoutlines.com/cdmarkers.html
__________________
Dx MDS RAEB 10% blasts + hypogammaglobulinemia, Sep 2011. Jan 2012 BMB - blasts down to 2% w/out treatment so BMT cancelled. Re-diagnosis RCMD. Watch and wait from Feb 2012. IVIg 5-weekly. New diagnosis Oct 2019 AML 23% blasts in marrow, 10% blasts in peripheral blood.
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