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Clinical Trials Considering or participating in research studies

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  #1  
Old Sun Dec 8, 2013, 05:43 AM
Birgitta-A Birgitta-A is offline
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Thumbs up More results from trials with T-cells

Hi All,
Now they report more results from the trials with T-cells that we have read about the latest years.
http://news.msn.com/science-technolo...-blood-cancers
Kind regards
Birgitta-A
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  #2  
Old Sun Dec 8, 2013, 02:09 PM
Mseth Mseth is offline
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Hi Birgitta-A,

Thanks for posting the link. It seems many people have alreasy benefited from this.

I wonder how gene therapy can work for MDS, and if and when it can be offered as a potential treatment option.

For low risk MDS, there is very little in the pipeline of treatment options, even though majority of MDS is low risk.
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Mother age 79, dx MDS RCMD low risk del 20q April 2013, no response to EPO, Danazol. pRBC tx dependent - 2 units every 3-4 weeks, exjade Dec 2013 - Mar2014, restarted Dec 2014
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  #3  
Old Sun Dec 8, 2013, 03:04 PM
sbk007 sbk007 is offline
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Thx Birgetta

I think because MDS is so rare there just isn't a lot of incentive monetary wise to get the interest of more scientists and drug companies to focus on it. The drug companies go by revenue per patient, so the population of leukemia patients, and other diseases is much more profitable. Sounds cold but that's the reality of it. You wont hear our President declare a war on MDS anytime soon..Hopefully one of these agents by chance will work for MDS patients.
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  #4  
Old Mon Dec 9, 2013, 07:18 AM
edithr edithr is offline
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sbk007, you are spot on.
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  #5  
Old Mon Dec 9, 2013, 07:24 AM
Birgitta-A Birgitta-A is offline
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MDS

Hi Mseth and sbk007,
As far as I understand this method could be used in many types of cancer. They don't have to show the effect in every type but work with the method until it is approved. My sister who had colon cancer was offered to participate in a trial with targeted T-cells 2008.
Kind regards
Birgitta-A
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  #6  
Old Wed Dec 11, 2013, 05:11 PM
DanL DanL is offline
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I spoke to UPENN recently and they indicated that they are at least several months away from even trying this on MDS/AML.
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MDS RCMD w/grade 2-3 fibrosis. Allo-MUD Feb 26, 2014. Relapsed August 2014. Free and clear of MDS since November 2014 after treatment with Vidaza and Rituxan. No longer experiencing nor treating CGVHD. Working on fixing long-term side effects of AVN in hips and cataracts in eyes. Life is good!
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  #7  
Old Thu Dec 12, 2013, 05:18 AM
Birgitta-A Birgitta-A is offline
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MDS

Hi Dan,
Yes, it will probably take years before MDS patients could try this method if it is working but we will have to wait just as long time for all new drugs they are trying now too (if they are working).
Kind regards
Birgitta-A
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  #8  
Old Thu Dec 12, 2013, 08:20 AM
Mseth Mseth is offline
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Estybon

Hi all,

In the ASCO update on MDS Beacon, there is some positive news on Estybon, for low risk transfusion dependent showing 50% success rate. Is this something to look forward to in the near future?
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Mother age 79, dx MDS RCMD low risk del 20q April 2013, no response to EPO, Danazol. pRBC tx dependent - 2 units every 3-4 weeks, exjade Dec 2013 - Mar2014, restarted Dec 2014
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  #9  
Old Thu Dec 12, 2013, 01:43 PM
Birgitta-A Birgitta-A is offline
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Rigosertib (Estybon)

Hi Mseth,
The drug Rigosertib iv is now in a Phase 3 trial as a second line drug for higher risk MDS. This means that they have to finish the trial and that the trial should show good effects/better effects than other second line treatments for these patients. They hope that the trial will be finished in the spring 2014. Then they have to write to FDA for approval and wait for answer - that will take many months.

Then they have oral Rigosertib for lower risk MDS. This drug is only in a Phase 2 trial and we don't know when this trial and the Phase 3 trial will be finished.

http://www.onconova.com/product-pipeline/rigosertib.php
Kind regards
Birgitta-A
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  #10  
Old Wed Dec 18, 2013, 09:25 AM
Mseth Mseth is offline
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Phase 2 Rigosertib

Hi Birgitta-A,

Is there any information on the phase 2 study for the oral drug from forum members who have enrolled and who have shared their experience?
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Mother age 79, dx MDS RCMD low risk del 20q April 2013, no response to EPO, Danazol. pRBC tx dependent - 2 units every 3-4 weeks, exjade Dec 2013 - Mar2014, restarted Dec 2014
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  #11  
Old Wed Dec 18, 2013, 01:42 PM
Birgitta-A Birgitta-A is offline
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Rigosertib, Estybon or ON 01910

Hi Mseth,
If you use the search function you will find this post: http://forums.marrowforums.org/showthread.php?t=2959
Kind regards
Birgitta
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  #12  
Old Wed Dec 18, 2013, 11:58 PM
Mseth Mseth is offline
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Hi Birgitta-A,

Thanks for the link. I will follow the information on the thread though it has not been updated for a while now.
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Mother age 79, dx MDS RCMD low risk del 20q April 2013, no response to EPO, Danazol. pRBC tx dependent - 2 units every 3-4 weeks, exjade Dec 2013 - Mar2014, restarted Dec 2014
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