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#1
Wed Apr 13, 2011, 07:28 AM
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Cyclosporine blood level peak
If you get your blood taken 45 min to an hour after you take your Cyclosporine, has it ever peaked to 1870? Does that sound like an extremely high peak to you?
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Edith, mom to Eric, dx 2/11 at age 15 with SAA, began ATG/CsA 3/11, switched to Tacrolimis 8/11, off all meds 9/11 and is now considered to have bone marrow failure not otherwise specified. 
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#2
Wed Apr 13, 2011, 09:11 AM
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Cyclosporine blood level peak
Hi EdithR,
When my husband was on Cyclosporine he was instructed not to take it until after his blood was drawn. That enabled them to get an accurate reading of the level in his blood. These were instructions from the National Institutes of Health in Bethesda, Md. where he has been in clinical trials since April, 2009 (Campath) for Hypocellular MDS. He is now the first guinea pig in a brand new clinical trial for his type of MDS for Promacta (Eltrombopag) in an attempt to increase his platelets and possibly his red cells. God Bless, Sally Last edited by Sally C : Wed Apr 13, 2011 at 10:40 AM. Reason: Left out information
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#3
Wed Apr 13, 2011, 02:00 PM
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The one time Ken forgot not to take it and got a peak reading, his CsA was 728 (as opposed to a trough of 130 a couple of weeks later). That was not immediately following ATG, however. He had already become tx-independant and his dosage had been tweaked down to a much lower maintenance level (200 mg/day) by then than what they'd started him on.
1870 does sound kind of high, but what is Eric's trough level? They seem to like to keep it as high as the patient can tolerate until they see a response. Even after we'd figured out what Ken's "safe for kidneys" dosage was, they raised it again (to 300) for a few months when they did his second ATG. Even though his creatinine was a bit high (1.4) during that time, they only lowered it when he started getting readings of 1.6 and 1.7. By that time he'd already responded to the second round.
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-Lisa, husband Ken age 60 dx SAA 7/04, dx hypo MDS 1/06 w/finding of trisomy 8; 2 ATGs, partial remission, still using cyclosporine
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#4
Wed Apr 13, 2011, 04:32 PM
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Eric's only finished ATG 2 weeks ago today, so the Cyclosporine dosage is being tinkered with. He started at 350 twice a day, he's down to 225 twice a day. From what I understand, trough is when they take blood 12 hours after your dose and just before you take your next one? If thats the case, we're doing that Thursday morning. Hopefully it'll be good.
__________________
Edith, mom to Eric, dx 2/11 at age 15 with SAA, began ATG/CsA 3/11, switched to Tacrolimis 8/11, off all meds 9/11 and is now considered to have bone marrow failure not otherwise specified.
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#5
Wed Apr 13, 2011, 06:30 PM
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My first doctor did not know enough to tell me not to take it before the blood draw.
It took an interested coworker to discover this on the internet.
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Dallas, Texas - Age 81 - Pure Red Cell Aplasia began March 2005 - Tried IVIG - Then cyclosporine and prednisone. Then Danazol, was added. Then only Danazol . HG reached 16.3 March 2015. Taken off all meds. Facebook PRCA group https://www.facebook.com/groups/PureRedCellAplasia/
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#6
Fri Apr 15, 2011, 03:38 PM
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The trough level was 225. Does this sound good?
__________________
Edith, mom to Eric, dx 2/11 at age 15 with SAA, began ATG/CsA 3/11, switched to Tacrolimis 8/11, off all meds 9/11 and is now considered to have bone marrow failure not otherwise specified.
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