Home         Forums  

Go Back   Marrowforums > Bone Marrow Failure Diseases > MDS
Register FAQ Search Today's Posts Mark Forums Read

MDS Myelodysplastic syndromes

Reply
 
Thread Tools Search this Thread
  #1  
Old Sat Feb 17, 2018, 11:49 AM
Delo3 Delo3 is offline
Member
 
Join Date: Feb 2018
Posts: 1
BMB questions

Hi-what a great group and site to try to make sense of things. I have had a low WBC for a number of years. It has continued to be low and is now staying in low ANC. A while back I had a BMB which didn't shed much light on my neutropenia. My count has stayed low and now primary care physician is asking me to follow up again with hematologist. My hematologist never explained anything (maybe nothing to explain) so I will look into new dr as well.

Most recent ANC was .6 other blood counts seem okay. I did have a number of years using benzene in work environment (before it was banned) which I am now thinking could be cause of low white count. While I know you aren't drs but any thoughts on these? It seems ridiculous that a dr can't follow up in explaining things. Is it ok to wait-or could something be treated if it were going on? Any thoughts appreciated! Thank you!!!

Leukopenia with a moderate absolute neutropenia with low-normal absolute lymphocyte monocyte count.

Rare activated/transformed lymphocytes noted. Some of the neutrophils seen on scanning show toxic changes and a left shift.

Cell Type % Range

Promyelocyte 0.0 (1.9-4.7)
Myelocyte 8.0 (8.5-16.9)
Metamyelocyte 4.8 (7.1-24.7)
Bands & PMNs 31.0 (13.2-26.4)
Monocyte 3.4 (0-0.6)
Basophilic Erythroblast 2.4 (0.4-2.4)
Poly & Ortho Erythroblast 34.0 (13.4-33.4)

A single lymphocytic aggregate, and a non-peritrabecular location, composed of small mature lymphocytes.

CELLS GATED: Lymphs
ANTIGENS NORMALLY PRESENT ON LEUKOCYTES
% OF GATED CELLS NORMAL RANGE
CD45 100 (>98%)
ANTIGENS NORMALLY PRESENT ON B CELLS
CD19 12 (2-18%)
CD20 15 (2-18%)
KAPPA 9 (1-15%)
LAMBDA 5 (1-15%)
KAPPA/LAMBDA
RATIO 1.
8 (1.0-3.0)
ANTIGENS NORMALLY PRESENT ON T CELLS
CD2 (PANT T, NK) 66 (62-92%)
CD3 (PAN T) 39 (62-92%)
CD5 (PAN T) 50 (62-92%)
CD7 (PAN T, NK) 76 (62-92%)
CD4 (T HELPER) 23 (35-58%)
CD8 (T SUP/CYT) 16 (16-32%)
CD4 TO CD8
RATIO 1.4 (1.0-3.0)

OTHER ANTIGENS:
CD5+CD20+ 0 (<1%)
CD19+CD10+ 0 (<3%)
CD56 26 (5-25%)

Four color flow cytometric evaluation of the specimen using CD45, CD19, CD20, Kappa, lambda, CD3, CD4, CD8, CD10, CD34, CD33 and CD117 show that 26 percent of all CD45 positive cells are lymphocytes, of which 12 percent of polyclonal B lymphocytes and 39 percent are T lymphocytes with unremarkable CD4 to CD8 ratio. NK are 26%. Blasts are one percent and are CD34 positive, CD117 positive and CD33 positive or negative.
Reply With Quote
  #2  
Old Mon Mar 26, 2018, 01:38 PM
JennyM JennyM is offline
Member
 
Join Date: Mar 2018
Location: Richmond, Virginia
Posts: 12
Cool BMB explain

Hi,

I understand your frustration but to understand your BM results you have to look at the pathology report examining your cells what you shared there is almost no way to determine what is going on. My report had all that to but when you go to the pathology report it will bw a paragraph of findings like mine

for ex:

The bone marrow aspirate shows trilineage hematopoiesis and full maturation. The M:E ratio is 1.2:1 due to erythroid hyperplasia. The erythoid cells also show megaloblastoid changes and dysplastic nuclei are seen in a few normoblasts. A few granulocytes show hypolobation and hypogranular features. There is an adequate number of megakaryocytes.
The core biopsy reveals a cellularity of 50% with erythroid hyperplasia.
Abnormal localization of immature precursors is not present.
Megakaryocytes are normal in number, but many cells are hypolobated and/or microcytic. Normal hematopoiesis and maturation are present in three cell lines. The bony trabeculae are unremarkable. PAS and Giemsa stains are confirmatory. Iron stain detects no stainable iron.

DIAGNOSIS:
BONE MARROW, POSTERIOR ILIAC CREST, SIDE NOT SPECIFIED, CORE BIOPSY AND ASPIRATE:
‐ Refractory cytopenia with multilineage dysplasia, mild.
Comment: The patient has anemia and leukopenia with mild dysplastic changes in three cell lines. The erythroid series shows megaloblastoid changes with dysplastic nuclei demonstrated in a small percentage of normoblasts. The granulocytes reveal hypolobation and/or hypogranularity in a few cells. The megakaryocytes show hypolobation and microcytic forms.

So this says the cells found those immature ect.
hope this helps
Reply With Quote
  #3  
Old Tue Mar 27, 2018, 09:08 AM
Leigh Clark Leigh Clark is offline
AAMDSIF Patient Educator
 
Join Date: Jun 2007
Posts: 22
HI Delo3 - If you need help locating an expert, contact AAMDSIF, 800-747-2820 x140 or email help@aamds.org.
Reply With Quote
Reply


Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Questions about agent use and length Fordad MDS 11 Sun Jan 15, 2017 11:26 AM
BMB help needed Wherenext MDS 3 Wed Jun 12, 2013 12:55 PM
Questions, Questions, Questions!! MrHandy2013 MDS 2 Sun May 26, 2013 07:35 PM
questions about bmb results mom23 Pediatrics 1 Thu Sep 3, 2009 01:09 AM
Newbie says hi, has questions! jennie MDS 8 Wed Oct 10, 2007 03:45 PM


All times are GMT -4. The time now is 05:23 AM.


Powered by vBulletin® Version 3.6.7
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Forum sites may contain non-authoritative and unverified information.
Medical decisions should be made in consultation with qualified medical professionals.
Site contents exclusive of member posts Copyright © 2006-2020 Marrowforums.org