Stem-cell scientists redefine how blood is made, toppling conventional 'textbook' vie

[curlygirl]

Stem-cell scientists redefine how blood is made, toppling conventional 'textbook' view from 1960s:
http://www.sciencedaily.com/releases...1105143819.htm

""Instead, through a series of experiments we have been able to finally resolve how different kinds of blood cells form quickly from the stem cell -- the most potent blood cell in the system -- and not further downstream as has been traditionally thought," says Dr. Dick, who holds a Canada Research Chair in Stem Cell Biology and is also Director of the Cancer Stem Cell Program at the Ontario Institute for Cancer Research."

...

""Four years ago, when we isolated the pure stem cell, we realized we had also uncovered populations of stem-cell like 'daughter' cells that we thought at the time were other types of stem cells," says Dr. Dick.

"When we burrowed further to study these 'daughters', we discovered they were actually already mature blood lineages. In other words, lineages that had broken off almost immediately from the stem cell compartment and had not developed downstream through the slow, gradual 'textbook' process."

[riccd2001]

Hi curlygirl: AFAIK the research credit for this work is...

F. Notta, S. Zandi, N. Takayama, S. Dobson, O. I. Gan, G. Wilson, K. B. Kaufmann, J. McLeod, E. Laurenti, C. F. Dunant, J. D. McPherson, L. D. Stein, Y. Dror, J. E. Dick. Distinct routes of lineage development reshape the human blood hierarchy across ontogeny. Science, 2015; DOI: 10.1126/science.aab2116

Good find!