ASH 2010 Splenectomy in Patients with MDS

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http://ash.confex.com/ash/2010/webpr...aper32874.html

1879 Splenectomy In Patients with MDS

Splenectomy in patients with MDS is a treatment option that is beeing applied very rare. "In most cases splenectomy was indicated for MDS patients with immune related thrombocytopenia."

This paper is a report about 33 splenectomies in patients with MDS in Moscow, Russia. Patients have been treated during 1994-2010.

Citation: "Splenectomy lead to sustained improvement of cytopenias in 16 cases (48%): decreased transfusion dependence in 14 ( 42%) and transfusion independence in 2 ( 6%)."

"Analysis of our 15-years study data give us a confidence to conclude that splenectomy still may be an adequate option for distinct forms of MDS (hypoplastic forms with bone marrow blast count less than 10%, refractory to initial immunosupressive treatment or refractory to transfusions),"...